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Table 4 Meta-analysis of TNF-α 857C/T polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic Model

Subgroup analysis

N (case/control)

OR(95%CI)

P*

I2

P#

P value

Begg

Egger

TT vs CC + CT

 

overall

3494/5279

1.124 (0.836,1.510)

0.437

0.0%

0.440

1.000

0.769

European

2139/3566

1.135 (0.753,1.710)

0.752

0.0%

0.546

0.624

0.577

North Asian

1158/1309

1.112 (0.726,1.703)

0.132

43.5%

0.627

0.624

0.994

HWE

1844/3078

1.230 (0.866,1.748)

0.466

0.0%

0.247

0.881

0.960

NO HWE

1453/1797

0.901 (0.519,1.564)

0.305

15.9%

0.711

0.602

0.839

TT + CT vs CC

 

overall

3494/5279

0.920 (0.825,1.027)

0.357

9.2%

0.137

0.283

0.467

European

2139/3566

0.978 (0.851,1.125)

0.498

0.0%

0.758

0.327

0.810

North Asian

1158/1309

0.835 (0.701,0.996)

0.327

13.7%

0.045

0.624

0.992

HWE

1844/3078

0.909 (0.793,1.041)

0.230

26.1%

0.167

0.881

0.641

NO HWE

1453/1797

0.942 (0.784,1.132)

0.428

0.0%

0.524

0.117

0.006

TT vs CC

 

overall

3494/5279

1.105 (0.820,1.488)

0.368

8.0%

0.513

0.858

0.833

European

2139/3566

1.140 (0.755,1.721)

0.704

0.0%

0.534

0.624

0.643

North Asian

1158/1309

1.067 (0.693,1.644)

0.109

47.1%

0.767

0.624

0.972

HWE

1844/3078

1.209 (0.848,1.724)

0.383

5.8%

0.295

0.881

0.996

NO HWE

1453/1797

0.890 (0.511,1.547)

0.291

19.1%

0.679

0.602

0.872

CT vs CC

 

overall

3494/5279

0.904 (0.807,1.012)

0.605

0.0%

0.081

0.474

0.429

European

2139/3566

0.966 (0.836,1.116)

0.610

0.0%

0.637

0.327

0.689

North Asian

1158/1309

0.812 (0.676,0.976)

0.649

0.0%

0.026

1.000

0.695

HWE

1844/3078

0.881 (0.765,1.015)

0.466

0.0%

0.080

0.652

0.632

NO HWE

1453/1797

0.946 (0.782,1.145)

0.513

0.0%

0.569

0.602

0.247

T vs C

 

overall

3494/5279

0.949 (0.862,1.045)

0.181

28.6%

0.288

0.371

0.496

European

2139/3566

0.994 (0.878,1.126)

0.442

0.0%

0.926

0.624

0.901

North Asian

1158/1309

0.886 (0.762,1.032)

0.108

47.2%

0.119

1.000

0.718

HWE

1844/3078

0.952 (0.846,1.071)

0.109

42.2%

0.416

0.652

0.796

NO HWE

1453/1797

0.943 (0.798,1.114)

0.330

9.7%

0.490

0.117

0.223

  1. *P value of Heterogeneity chi-squared
  2. #P value of Pooled statistic
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BMC Medical Genetics

ISSN: 1471-2350

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