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Fig. 1 | BMC Medical Genetics

Fig. 1

From: Case report: progressive familial intrahepatic cholestasis type 3 with compound heterozygous ABCB4 variants diagnosed 15 years after liver transplantation

Fig. 1

a Histology of explanted native liver showing biliary cirrhosis with annular fibrosis delimiting irregular parenchymal nodules (PicroSirius staining, × 15) and b moderate septal inflammation with some ductular reaction, canalicular bilirubinostasis and cholestasis changes in periseptal hepatocytes (H&E staining, × 120).c Immunochemistry study of the patient’s explanted native liver showing typical and even canalicular distribution of BSEP staining; d whereas the pattern of MDR3 canalicular staining is inconsistent and granular cytoplasmic signal observed within a proportion of hepatocytes. Within the control healthy liver, e regular canalicular BSEP and f MDR3 staining were observed

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BMC Medical Genetics

ISSN: 1471-2350

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