Fig. 3

Immunohistochemical staining for mismatch repair proteins of the colon tumors in this patient’s family. By immunohistochemistry, the tumor of this patient’ s father; II-3 and brother; III-7 had an intact expression of MSH6. The rest of the mismatch repair proteins showed the same staining pattern of this patient; negative for MLH1 and PMS2, positive for MSH2