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Table 6 Frequencies of common allele combinations of OPG, TGFβ1, RELN and Chromosome 11 SNPs in OTSC cases and controls

From: Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis

 

Frequency

Over all

Females

Males

Allele combinations

Cases

Controls

p-value

Cases

Controls

p-value

Cases

Controls

p-value

G-C-A-C-A-G

0.2703

0.2322

0.4113

0.2715

0.2367

0.5416

0.1387

0.3055

0.0349

G-C-G-C-A-G

0.1923

0.1662

0.5235

0.1888

0.1735

0.7609

0.2541

0.1662

0.2594

C-C-A-C-A-G

0.0669

0.1869

0.0004

0.0476

0.1732

0.0008

0.2363

0.1019

0.0609

C-C-A-T-G-G

0.1215

0.0533

0.0281

0.1077

0.0779

0.4392

0.0179

0.1569

0.0094

  1. The allele combination analysis of the six SNPs in the following order: rs2073618, rs1800472, rs39335, rs39350, rs39374 and rs494252 revealed significant differences between cases and controls with sex-specific associations in C-C-A-C-A-G for females and G-C-A-C-A-G and C-C-A-T-G-G for males
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BMC Medical Genetics

ISSN: 1471-2350

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