Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

BMC Medical Genetics

Table 1 Distributions of characteristics between selected PE patients and Controls

Characteristics	Control (n = 330, (%))	EOPE (n = 66, (%))	LOPE (n = 206, (%))	p
Maternal age, years
< 25	44(13.33) ^a	6(9.09) ^a	26(12.62) ^a	< 0.001
25–30	177(53.64)	24(36.36)	66(32.04)
> 30	109(33.03)	36(54.55)	114(55.34)
Education, years
≤ 12	118(35.76)	26(39.39)	90(43.69)	0.186
> 12	212	40(60.61)	116(56.31)
Nulliparous
Yes	152 (46.06) ^b	42(63.64) ^b	96(46.60) ^b	0.028
No	178 (53.94)	24(36.36)	106(53.40)
Active and/or passive smoking
Yes	102 (30.90) ^b	31(46.97) ^b	61(29.61) ^b	0.024
No	228 (69.09)	35(53.03)	145(70.39)
Fetal gender
Male	167 (50.61)	36(54.55)	86(41.75)	0.072
Female	163 (49.39)	30(45.45)	120(58.25)
GDM
Yes	17 (5.15) ^c	6(9.09) ^c	40(19.42) ^c	< 0.001
No	313 (94.85)	60(90.91)	166(80.58)

^aControl compared with EOPE, p < 0.0125, control compared with LOPE, p < 0.0125, EOPE compared with LOPE, p > 0.0125;
^bControl compared with EOPE, p < 0.0125, control compared with LOPE, p > 0.0125, EOPE compared with LOPE, p < 0.0125;
^cControl compared with EOPE, p > 0.0125, control compared with LOPE, p < 0.0125, EOPE compared with LOPE, p < 0.0125;
Abbreviation: PE preeclampsia, EOPE early onset preeclampsia, LOPE late onset preeclampsia, GDM Gestational Diabetes Mellitus

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