Table 4 Genetic association analysis for the investigated CYP450 candidate gene polymorphisms using different genetic models
Gene | SNP ID | Category Test | Odds Ratio | 95% CI | Chi square* |
|---|---|---|---|---|---|
CYP19A1 | rs7176005 | Het (CT) vs Common Hz (CC) | 1.51 | 1–2.27 | 3.87 |
Rare Hz (TT) vs Het (CT) | 4.68 | 1.01–21.69 | 4.57 | ||
Rare Hz (TT) vs Common Hz (CC) | 7.05 | 1.55–32.05 | 8.44 | ||
rs6493497 | Het (AG) vs Common Hz (GG) | 1.39 | 0.92–2.1 | 2.43 | |
Rare Hz (AA) vs Het (AG) | 4.93 | 1.06–22.9 | 4.94 | ||
Rare Hz (AA) vs Common Hz (GG) | 6.84 | 1.5–31.13 | 8.13 | ||
rs700519 | Het (AG) vs Common Hz (GG) | 1.33 | 0.55–3.22 | 0.39 | |
Rare Hz (AA) vs Het (AG) | NA | NA | NA | ||
Rare Hz (AA) vs Common Hz (GG) | NA | NA | NA | ||
rs10046 | Het (AG) vs Common Hz (GG) | 1.05 | 0.69–1.61 | 0.05 | |
Rare Hz (AA) vs Het (AG) | 0.76 | 0.45–1.28 | 1.06 | ||
Rare Hz (AA) vs Common Hz (GG) | 0.8 | 0.45–1.4 | 0.62 | ||
rs4646 | Het (AC) vs Common Hz (CC) | 1.02 | 0.68–1.51 | 0.01 | |
Rare Hz (AA) vs Het (AC) | 0.98 | 0.5–1.9 | 0 | ||
Rare Hz (AA) vs Common Hz (CC) | 0.99 | 0.52–1.89 | 0 | ||
CYP2C9 | rs1799853 | Het (CT) vs Common Hz (CC) | 0.88 | 0.56–1.39 | 0.3 |
Rare Hz (TT) vs Het (CT) | 0.85 | 0.29–2.46 | 0.09 | ||
Rare Hz (TT) vs Common Hz (CC) | 0.74 | 0.27–2.05 | 0.33 | ||
CYP2C19 | rs4244285 | Het (AG) vs Common Hz (GG) | 1.52 | 0.91–2.53 | 2.58 |
Rare Hz (AA) vs Het (AG) | 2.09 | 0.21–21.1 | 0.41 | ||
Rare Hz (AA) vs Common Hz (GG) | 3.18 | 0.33–30.84 | 1.11 | ||
CYP1B1 | rs10175368 | Het (CT) vs Common Hz (CC) | 1.34 | 0.9–2 | 2.11 |
Rare Hz (TT) vs Het (CT) | 0.78 | 0.38–1.6 | 0.46 | ||
Rare Hz (TT) vs Common Hz (CC) | 1.05 | 0.53–2.11 | 0.02 | ||
CYP1A2 | rs762551 | Het (AC)vs Common Hz (AA) | 1.14 | 0.76–1.71 | 0.42 |
Rare Hz (CC) vs Het(AC) | 0.51 | 0.28–0.93 | 4.92 | ||
Rare Hz (CC)vs Common Hz(AA) | 0.59 | 0.33–1.06 | 3.18 |