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Table 2 Metabolic syndrome (MetS) associated loci in females. Discovery stage was GWAS for MetS in each sex-stratified group of KARE study. Overall association results (Pmeta) were obtained from meta-analyses combining Discover (KARE) and Replication (Rural1816, Rural3667 and HEXA) stages

From: Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females

CHR

SNP

BP (GRCh37)

Candidate gene

EA

EAF

Female

Male

Combining female & male

Discovery

Replication

Overall

KARE

Rural1816

Rural3667

HEXA

OR

PKARE

OR

PRural1816

OR

PRural3667

OR

PHEXA

OR

Pmeta

N

OR

Pmeta

N

OR

Pmeta

N

1

rs2209363

187,163,851

LINC01036

C

0.18

0.67

5.32E-04

–

–

0.72

1.27E-02

–

–

0.69

2.11E-05

2496

1.08

3.64E-01

1870

0.88

4.24E-02

4366

2

rs768072

160,233,383

BAZ2B

T

0.25

0.72

7.66E-04

–

–

0.72

1.08E-02

–

–

0.72

2.41E-05

2596

0.96

5.72E-01

1922

0.82

2.34E-04

4518

2

rs284544

217,309,111

SMARCAL1

A

0.21

1.51

1.65E-04

–

–

1.36

1.77E-02

–

–

1.44

1.06E-05

2572

0.97

7.25E-01

1907

1.15

1.01E-02

4479

2

rs284541

217,368,839

RPL37A

T

0.20

1.51

2.56E-04

–

–

1.34

2.90E-02

–

–

1.43

2.66E-05

2531

0.92

3.28E-01

1879

1.12

4.59E-02

4410

2

rs2012243

217,412,087

LOC101928180

A

0.21

1.50

1.77E-04

–

–

1.30

3.98E-02

–

–

1.41

2.77E-05

2599

0.93

3.59E-01

1924

1.11

6.45E-02

4523

6

rs10947646

36,881,535

C6orf89

G

0.02

0.33

2.66E-04

–

–

–

–

0.35

4.97E-02

0.34

3.46E-05

3196

1.48

9.18E-02

2353

0.78

1.28E-01

5549

8

rs2283113

17,880,243

PCM1

A

0.47

1.32

1.42E-03

–

–

1.31

1.15E-02

–

–

1.31

4.77E-05

2524

1.07

3.10E-01

1869

1.18

3.61E-04

4393

9

rs16923249

5,592,145

PDCD1LG2-RIC1

A

0.03

0.44

4.26E-04

–

–

–

–

0.39

2.89E-02

0.43

3.46E-05

3214

1.02

9.29E-01

2360

0.73

1.28E-02

5574

13

rs9568558

51,810,953

FAM124A

G

0.26

1.33

4.77E-03

–

–

1.39

1.11E-02

1.24

1.15E-01

1.32

4.98E-05

3436

0.99

8.60E-01

2466

1.13

9.69E-03

5902

13

rs9516416

95,103,694

DCT

C

0.13

0.68

2.96E-03

0.68

3.71E-01

–

–

0.55

2.16E-03

0.64

2.04E-05

3166

1.00

9.64E-01

2325

0.82

4.17E-03

5491

13

rs6492111

109,055,846

TNFSF13B-MYO16

C

0.02

0.35

3.83E-03

0.96

9.66E-01

–

–

0.31

1.74E-03

0.35

3.47E-05

3176

0.75

2.91E-01

2325

0.54

7.51E-04

5501

16

rs4072617

20,178,590

GPR139

A

0.19

1.36

3.83E-03

1.41

4.70E-01

1.36

3.02E-02

1.54

2.91E-03

1.41

2.84E-06

3954

0.97

6.36E-01

2857

1.15

4.09E-03

6811

19

rs8107274

37,285,393

ZNF790

C

0.03

4.56

5.27E-04

–

–

2.26

1.34E-02

–

–

2.91

4.92E-05

2579

0.85

4.67E-01

1908

1.40

2.94E-02

4487

21

rs2827976

24,600,783

LOC105372747

G

0.19

0.69

5.47E-04

0.61

1.50E-01

–

–

0.72

3.74E-02

0.70

1.99E-05

3205

0.97

6.87E-01

2357

0.83

8.28E-04

5562

  1. Information for the SNP ID and chromosomal position is based on NCBI genome build 37/hg19
  2. The ‘-’ sign indicates data not available
  3. CHR chromosome, BP Physical position (base-pair), EA effect allele, EAF effect allele frequency, OR Odds Ratio, N sample size of meta-analysis combining cases and controls
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BMC Medical Genetics

ISSN: 1471-2350

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