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Table 4 Phenotypic Associations With Candidate Genes Previously Related To Stroke, Dementia And Brain MRI Or Cognitive Function Phenotypes: Phenotype-SNP Associations With A GEE Or FBAT P-Value < 0.001

From: Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study

Gene

Phenotype

SNP

Chr

Physical Position

GEE_Pvalue

FBAT_Pvalue

NGFB

AHPV

rs10489531

1

115495044

9.7 × 10-4

0.046

PRSS25

ATBV

rs363685

2

74726491

2.5 × 10-4

 
 

ATCBV

rs363685

2

74726491

5.7 × 10-5

 

GRK4

F1

rs2105380

4

3019934

0.276

5.8 × 10-4

HMGE

ATBV

rs4689584

4

7179291

0.035

1.0 × 10-4

APBB2

F1

rs10517001

4

41051593

1.4 × 10-4

0.009

SNCA

Sim

rs3796661

4

91044685

2.6 × 10-4

0.332

 

AHPV

rs2870028

4

91122391

3.2 × 10-4

0.180

 

AHPV

rs7678651

4

91125549

1.3 × 10-4

0.102

 

AHPV

rs10516848

4

91132390

1.6 × 10-4

0.115

PDE4D

WRAT

rs295973

5

58945866

5.3 × 10-4

0.060

 

Sim

rs10514882

5

59170282

6.4 × 10-5

 
 

Sim

rs9292216

5

59187886

2.4 × 10-4

 

DCDC2

F3

rs10484657

6

24224829

0.017

9.5 × 10-4

 

ATCBV

rs10484657

6

24224829

6.0 × 10-4

0.015

THBS2

ATBV

rs6937001

6

169382718

6.0 × 10-4

0.021

GATA4

WRAT

rs7006733

8

11645399

0.034

3.1 × 10-4

NRG1

ATCBV

rs1383893

8

31844190

0.407

8.9 × 10-4

 

F2

rs10503906

8

32291504

0.187

4.2 × 10-4

 

AFBV

rs10503919

8

32519284

1.9 × 10-4

0.288

 

BMRIZLWMH

rs10503926

8

32660758

8.7 × 10-5

0.009

 

VMV

rs10503927

8

32662772

2.0 × 10-4

0.002

VLDLR

ATCBV

rs502309

9

2562909

5.4 × 10-6

0.157

 

Nam

rs2168136

9

2584577

1.6 × 10-4

0.006

NTRK2

F1

rs10512152

9

84457363

7.6 × 10-5

0.018

 

AFBV

rs1573219

9

84617176

0.174

5.6 × 10-4

 

AFBV

rs7038866

9

84617461

0.146

3.6 × 10-4

TEK

ATBV

rs628873

9

27162838

4.9 × 10-4

0.051

BACE1

APBV

rs1261791

11

116705848

0.021

3.1 × 10-4

SORL1

Sim

rs1131497

11

121007955

0.008

3.2 × 10-6

 

Sim

rs726601

11

120986617

0.046

8.2 × 10-4

VWF

ATCBV

rs216903

12

5975760

0.149

9.5 × 10-4

A2M

F3

rs2889717

12

9178068

9.3 × 10-5

 

LRRK2

WRAT

rs2249017

12

38847487

5.5 × 10-4

0.061

 

F1

rs7975693

12

38874945

8.1 × 10-5

0.005

 

AFBV

rs10506151

12

38957265

3.7 × 10-4

1.6 × 10-4

 

ATBV

rs10506151

12

38957265

9.7 × 10-4

0.371

CNTN1

ATBV

rs10506176

12

39561067

8.8 × 10-4

0.622

LTA4H

Sim

rs10492226

12

94906457

6.7 × 10-4

 

IGF1

ALLV

rs1980236

12

101270359

0.046

9.3 × 10-4

LTB4R2

APBV

rs724165

14

23876069

4.5 × 10-4

0.162

NTRK3

ALLV

rs10520671

15

86347520

6.2 × 10-5

0.062

CCL2

WRAT

rs1024612

17

29573469

0.231

7.0 × 10-4

PRKCA

F1

rs9303511

17

62158093

0.068

7.9 × 10-4

CST3

AOBV

rs1158167

20

23526189

6.5 × 10-4

0.032

PRNP

APBV

rs2326510

20

4649211

0.000718

0.064794

BACE2

F1

rs2007397

21

41438062

0.030

2.2 × 10-4

 

F1

rs10483073

21

41499167

3.5 × 10-4

 
 

Nam

rs10483073

21

41499167

1.7 × 10-4

 
  1. *Genes in bold are highlighted in discussion section.
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BMC Medical Genetics

ISSN: 1471-2350

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