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Table 2 Nominally significant associations between prolactin (PRL) and prolactin receptor (PRLR) tagSNPs and plasma PRL levels

From: A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort

PRL

      

SNP

SNP Name

N (%)

Genotype

LS meansa (95% CI)

pb

"BLOCK" 2

      

SNP 33

rs1341238

167 (64.98)

GG

7.15

(6.35 – 8.06)

0.025

  

65 (25.29)

AG

9.23

(7.68 – 11.09)

 
  

25 (9.73)

AA

9.02

(6.69 – 12.16)

 

SNP 34

rs9466314

248 (96.50)

AA

7.67

(6.94 – 8.49)

0.039

  

8 (3.11)

AT

10.48

(6.25 – 17.58)

 
  

1 (0.39)

TT

31.75

(7.69 – 131.02)

 

SNP 39

rs3756824

246 (81.19)

CC

7.56

(6.86 – 8.34)

0.035

  

56 (18.48)

CG

9.73

(8.00 – 11.82)

 
  

1 (0.33)

GG

6.15

(1.55 – 24.49)

 

SNP 44

rs2244502

145 (47.85)

AA

6.96

(6.15 – 7.88)

0.002

  

126 (41.58)

AT

8.64

(7.60 – 9.82)

 
  

32 (10.56)

TT

10.30

(7.91 – 13.41)

 

BLOCK 3

      

SNP 54

rs849886

83 (25.54)

CC

9.33

(7.83 – 11.13)

0.048

  

157 (48.31)

CT

8.22

(7.31 – 9.24)

 
  

85 (26.15)

TT

7.27

(6.15 – 8.59)

 

BLOCK 4

      

SNP 62

rs849870

191 (64.09)

CC

8.72

(7.81 – 9.72)

0.013

  

96 (32.21)

CT

7.28

(6.30 – 8.41)

 
  

11 (3.69)

TT

5.66

(3.69 – 8.70)

 

SNP 65

rs849872

142 (47.65)

TT

8.96

(7.92 – 10.14)

0.018

  

123 (41.28)

CT

7.47

(6.59 – 8.48)

 
  

33 (11.07)

CC

6.93

(5.42 – 8.85)

 

PRLR

      

BLOCK 4

      

SNP 73

rs10941235

135 (49.45)

CC

8.97

(7.78 – 10.33)

0.042

  

107 (39.19)

CT

7.09

(6.13 – 8.20)

 

SNP 148

rs37364

136 (49.1)

TT

7.34

(6.44 – 8.35)

0.037

  

106 (38.27)

GT

8.49

(7.32 – 9.86)

 
  

35 (12.64)

GG

9.72

(7.50 – 12.6)

 
  1. AA, African Americans; NH, Native Hawaiians; JA, Japanese Americans; LA, Latinas, WH, Whites.
  2. a Least square means of prolactin levels and 95% confidence interval; LS means adjusted for age, ethnicity, and assay batch.
  3. b P-value for test of trend.
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BMC Medical Genetics

ISSN: 1471-2350

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