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Table 4 Association between 5 CFH haplotypes and premature heart disease

From: Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Haplotypes

Sequence

W1

Expected(W)

Variance(W)

P-value

H1

CCGACG

133

131.9

47.9

0.88

H2

CCGAAG

279

280.4

97.5

0.89

H3

CTGGAG

181

184.5

61.6

0.66

H4

TTGAAA

167

167.7

58.5

0.92

H5

CTAAAG

166

161.5

56.6

0.55

  1. 1 W = X+Y where X is the number of transmissions of the haplotype from heterozygote parents to affected siblings (TDT) and Y is the number of the occurrences of the haplotype in affected sibs in remaining informative families (S-TDT).
  2. The 6 alleles in the Sequence column from left to right are from rs800292 to rs2284664 according to their positions in the CFH gene.
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BMC Medical Genetics

ISSN: 1471-2350

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