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Table 3 Heart and brain tag methylation

From: Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging

Tissue

CSX methylation

SOX10 methylation

BGN methylation

 

≤ 5 yrs old

> 5 yrs old

p*

≤ 5 yrs old

> 5 yrs old

p

≤ 5 yrs old

> 5 yrs old

p

Heart

9.6% (64)**

18.3% (161)

< 0.001

43.4% (63)

81.7% (143)

< 0.001

4.2% (37)

3.6% (94)

0.77

Right heart

 

15.9% (48)

0.36

 

81.1% (40)

0.79

 

4.4% (31)

0.56

Left heart

 

19.4% (113)

  

81.9% (103)

  

3.2% (63)

 
 

<

  

<

  

<

  
 

≤ 2 yrs old

> 2 yrs old

 

≤ 2 yrs old

> 2 yrs old

 

≤ 2 yrs old

> 2 yrs old

 

Brain

3.8% (56)

17.3% (160)

< 0.001

44.4% (56)

68.1% (160)

< 0.001

5.6% (40)

8.3% (104)

0.34

Cortex

 

14.1% (112)

0.005

 

61.6% (112)

< 0.001

 

8.7% (72)

0.71

Cerebellum

 

24.7% (48)

  

83.1% (48)

  

7.3% (32)

 
  1. * two sided t-test
  2. ** numbers of examined tags
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BMC Medical Genetics

ISSN: 1471-2350

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