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Table 2 Prevalence of APOA5 gene variants -1131T>C and S19W in Asian Indians and UK white subjects.

From: Triglyceride associated polymorphisms of the APOA5gene have very different allele frequencies in Pune, India compared to Europeans

SNP

-1131T>C

S19W

 

TT

TC

CC

Carrier* Frequency (95% CIs)

Less common allele Frequency (95% CIs)

SS

SW

WW

Carrier* Frequency (95% CIs)

Less common allele Frequency (95% CIs)

Pune Indians (n = 524)

336

170

18

0.36 (0.32–0.40)

0.20 (0.17–0.22)

497

27

0

0.05 (0.03–0.07)

0.03 (0.02–0.04)

UK whites (n = 237)

218

19

0

0.08 (0.05–0.11)

0.04 (0.02–0.06)

210

26

1

0.11 (0.07–0.15)

0.06 (0.04–0.08)

P value

    

<0.00001

    

0.0015

  1. Asian Indians (adults from the Pune Children Study) and UK white subjects (adults from the Plymouth EarlyBird study).
  2. P values are calculated for differences in genotype frequencies between Pune Indians and UK white subjects. *Carrier frequency indicates individuals carrying at least one copy of the less common allele at either polymorphism. Neither population showed any deviation from HWE for either polymorphism (p > 0.05).
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BMC Medical Genetics

ISSN: 1471-2350

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