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Table 7 Haplotype analyses when comparing two HLA loci

From: Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Haplotype combination

Global Score Statistics

DF

p value

Most significant haplotype

Haplotype-specific score statisticsa

p valuea

    

Haplotype

Population Frequency (%)

  

DQA1+DQB1

62.7

58

0.311

0201~0302

1.2

3.01

0.003

DQA1+DRB1

91.8

71

0.049

0102~1601

11.6

3.04

0.002

DQA1+DRB3-5

50.6

51

0.491

0101~B3-0202

4.8

-2.39

0.017

DQB1+DRB1

125.7

119

0.319

0604~1301

1.1

2.36

0.018

DQB1+DRB3-5

66.2

77

0.806

0301~B3-0201

1.9

2.02

0.044

DRB1+DRB3-5

115.1

114

0.453

1601~B5-0101

10.3

2.35

0.019

  1. DF: degrees of freedom; AAA: abdominal aortic aneurysm.
  2. a Haplo.stats program [29] was used for the analysis. Rare haplotypes with frequencies of ≤ 0.01 were pooled into a single baseline group. Results on haplotypes with only two loci are reported.
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BMC Medical Genetics

ISSN: 1471-2350

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