Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients

Delgado, Ivan J; Kim, Dong Sun; Thatcher, Karen N; LaSalle, Janine M; Van den Veyver, Ignatia B

doi:10.1186/1471-2350-7-61

BMC Medical Genetics

Table 1 Genes with lower expression in mutant samples on microarray analysis. This table contains a list of genes with lower expression in mutant T-lymphocyte clones by one-way ANOVA analysis (p < 0.05). * indicates >1.5-fold change in expression level and ** indicates >2-fold change in expression level.

From: Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients

No.	Gene Name	P-value	Common name	Genbank No.	Description
1**	201160_s_at	0.000593	CSDA	AL556190	cold shock domain protein A
2*	201417_at	0.00108	SOX4	AL136179	SRY (sex determining region-Y) box 4
3	202565_s_at	0.00385	SVIL	NM_003174	supervillin
4	204860_s_at	0.00453	BIRC1	AI817801	Transcribed seq with strong similarity BIR1
5	215333_x_at	0.00459	GSTM1	X08020	glutathione S-transferase M1
6*	210763_x_at	0.00546	NCR3	AF031137	natural cytotoxicity triggering receptor 3
7**	217979_at	0.00821	TM4SF13	NM_014399	transmembrane 4 superfamily member 13
8	208524_at	0.0117	GPR15	NM_005290	G protein-coupled receptor 15
9**	215440_s_at	0.012	BEXL1	AL523320	hypothetical protein FLJ10097
10	213193_x_at	0.0157	TRBC1	AL559122	T cell receptor beta chain BV20S1 BJ1-5 BC1 mRNA
11	220131_at	0.0174	FXYD7	NM_022006	FXYD domain containing ion transport regulator 7
12	204550_x_at	0.0175	GSTM1	NM_000561	glutathione S-transferase M1
13	212739_s_at	0.0186	NME4	AL523860	non-metastatic cells 4, protein expressed in
14*	220684_at	0.0187	TBX21	NM_013351	T-box 21
15	203030_s_at	0.0195	PTPRN2	AF007555	protein tyrosine phosphatase, receptor type N polypeptide 2
16	219693_at	0.0232	AGPAT4	NM_020133	1-acylglycerol-3-phosphate O-acyltransferase 4
17*	219654_at	0.0245	PTPLA	NM_014241	protein tyrosine phosphatase-like, member a
18	217764_s_at	0.0245	RAB31	AF183421	RAB31, member RAS oncogene family
19*	217671_at	0.0247	RFX3	BE466926	regulatory factor X, 3 (Influences HLA class II expression)
20**	204232_at	0.025	FCER1G	NM_004106	Fc fragment of IgE, high affinity receptor for γ-polypeptide
21*	1405_i_at	0.0298	CCL5	M21121	chemokine (C-C motif) ligand 5
22**	206170_at	0.0308	ADRB2	NM_000024	adrenergic, beta-2-, receptor, surface
23**	211583_x_at	0.0317	NCR3	AF031136	natural cytotoxicity triggering receptor 3
24	202279_at	0.0328	C14orf2	NM_004894	chromosome 14 open reading frame 2
25	214012_at	0.0333	ARTS-1	BE551138	type 1 TNF receptor shedding aminopeptidase regulator
26	204396_s_at	0.0346	GRK5	NM_005308	G protein-coupled receptor kinase 5
27**	211010_s_at	0.0349	NCR3	AF031138	natural cytotoxicity triggering receptor 3
28	208791_at	0.0351	CLU	M25915	clusterin
29**	219529_at	0.0383	CLIC3	NM_004669	chloride intracellular channel 3
30	217104_at	0.0385	LOC283687	AL109714	hypothetical protein LOC283687
31	213280_at	0.0397	GARNL4	AK000478	GTPase activating RANGAP domain-like 4
32	202234_s_at	0.04	SLC16A1	BF511091	solute carrier family 16, member 1
33**	215006_at	0.0404		AK023816	CDNA FLJ13754 fis, clone PLACE3000362
34	204883_s_at	0.0409	HUS1	AI968626	HUS1 checkpoint homolog (S. pombe)
35**	217963_s_at	0.0409	NGFRAP1	NM_014380	nerve growth factor receptor (TNFRSF16) ass. protein 1
36**	212070_at	0.0419	GPR56	AL554008	G protein-coupled receptor 56
37**	202363_at	0.042	SPOCK1	AF231124	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)
38*	206974_at	0.0427	CXCR6	NM_006564	chemokine (C-X-C motif) receptor 6
39	200965_s_at	0.0433	ABLIM1	NM_006720	actin binding LIM protein 1
40	219457_s_at	0.045	RIN3	NM_024832	Ras and Rab interactor 3
41**	213915_at	0.0452	NKG7	NM_005601	natural killer cell group 7 sequence
42	215411_s_at	0.0463	C6orf4	AL008730
43*	212274_at	0.0484	LPIN1	AV705559	AV705559ADB Homo sapiens cDNA clone ADBAPE04 5'
44	219155_at	0.049	PITPNC1	NM_012417	phosphatidylinositol transfer protein, cytoplasmic 1

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ISSN: 1471-2350

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