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Table 5 Results of stepwise multiple logistic regression analysis for the GSTM1 genotype (variable): final significant variables in the model

From: T null and M nullgenotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking

Risk Factor (variables)

Odds ratio

[95% C.I]

pvalue

GSTM1 Genotype (Mwild vs. Mnull)

8.90

6.32 – 12.5

< .001

Hypertension

2.49

1.74 – 3.57

< .001

Hypercholesterolemia

1.39

1.10 – 1.81

.015

Obesity

2.10

1.59 – 2.75

< .001

Smoking

2.82

1.87 – 4.28

< .001

Genotype (Mwild vs. Mnull) × smoking

0.469

0.26 – 0.85

.012

  1. GSTM1 genotype × smoking interaction was entered jointly into the multiple logistic regression analysis. Other factors were entered disjointedly. After analysis, the genotype × smoking interaction was retained in the model and therefore is shown in the above table.
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BMC Medical Genetics

ISSN: 1471-2350

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