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Table 6 Serum Immunoglobulin Concentrations in Index Patients with Significantly Associated HLA-A and -B Haplotypes.1

From: HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Number of Significantly Associated Haplotypes

0

1

2

Serum IgG, mg/dL (n)

734 ± 273 (45)

735 ± 287 (112)

749 ± 257 (33)

Serum IgA, mg/dL (n)

167 ± 92 (48)

157 ± 117 (109)

169 ± 71 (33)

Serum IgM, mg/dL (n)

108 ± 70 (46)

116 ± 96 (110)

115 ± 108 (34)

  1. 1 These data are expressed as mean ± 1 SD. Significantly associated haplotypes were defined as those that occurred with significantly greater frequency in CVID and IgGSD index cases than in control subjects. These six haplotypes were: A*01-B*08, A*02-B*44, A*03-B*07, A*03-B*14, A*31-B*40, and A*32-B*14 (see Table 4). There were no significant differences in the mean values of IgG, IgA, or IgM in the index patients grouped by inheritance of significantly associated haplotypes.
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BMC Medical Genetics

ISSN: 1471-2350

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