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Table 1 Characteristics of Index Patients with CVID and IgGSD.1

From: HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Characteristic

CVID (n = 114)

IgGSD (n = 126)

Men: Women

32: 82

38: 88

Age at Diagnosis, y (range)

54 ± 16 (21 – 87)

51 ± 13 (18 – 89)

Serum Total IgG, mg/dL (range)

527 ± 115 (140 – 697)

953 ± 199 (700 – 1751)

Deficient IgG Subclass(es)

Percentage (n)

Percentage (n)

1, 3

38.6 (44)

8.7 (11)

1

16.7 (19)

17.5 (22)

1, 2, 3

12.3 (14)

0

3

7.0 (8)

52.4 (66)

1, 2

7.0 (8)

0

1, 3, 4

7.0 (8)

0

1, 4

5.3 (6)

3.2 (4)

2, 3

3.5 (4)

1.6 (2)

1, 2, 3, 4

2.6 (3)

0

2

0.9 (1)

3.2 (4)

1, 2, 4

0.9 (1)

0

4

0

7.9 (10)

3, 4

0

4.8 (6)

2, 3, 4

0

0.8 (1)

Index Patients with Serum IgA Deficiency, % (n)

21.1 (24)

9.5 (12)

Index Patients with Serum IgM Deficiency, % (n)

18.4 (21)

7.9 (10)

  1. 1 By definition, all probands with CVID had subnormal serum concentrations of total IgG at diagnosis; mean serum IgG concentrations were significantly lower in CVID (p < 0.000.1; two-tail t-test). The percentage of index patients with IgA deficiency was significantly greater in CVID (p = 0.0293; Chi-square test). The percentage of index patients with IgM deficiency was significantly greater in CVID (p = 0.0156; Chi-square test).
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BMC Medical Genetics

ISSN: 1471-2350

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