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Table 3 Power to Detect Linkage as a Function of λS, θ, and Type I Error Rate (α)

From: The Siblings With Ischemic Stroke Study (SWISS) Protocol

 

α

 

0.10

0.05

0.0001

λS

θ = 0.050

θ = 0.075

θ = 0.050

θ = 0.075

θ = 0.050

θ = 0.075

2.0

0.98

0.95

0.96

0.90

0.40

0.24

2.5

1.00

0.99

1.00

0.98

0.74

0.52

3.0

1.00

1.00

1.00

1.00

0.92

0.73

4.0

1.00

1.00

1.00

1.00

1.00

0.92

  1. α, type I error; θ, recombination fraction (which is related to the distance between the marker and trait loci); λS, locus-specific relative risk to siblings.
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BMC Medical Genetics

ISSN: 1471-2350

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