Table 2 Distributionof APOE genotypes and alleles in the case-control association study
Type I | Type I | P | Type I | Type I | P | |
|---|---|---|---|---|---|---|
diabetes | diabetes | value | diabetes | diabetes | Value | |
subjects | subjects | subjects | subjects | |||
with | without | with | without | |||
nephropathy | nephropathy | retinopathy | retinopathy | |||
(DN+) | (DN-) | (DR+) | (DR-) | |||
n (%) | n (%) | n (%) | n (%) | |||
m/f (%/%) | m/f (%/%) | m/f (%/%) | m/f (%/%) | |||
74 (100) | 92(100) | 76 (100) | 96(100) | |||
Total subjects | 40/34 | 40/52 | 34/42 | 50/46 | ||
(54.0/46.0) | (43.5/56.5) | (44.7/55.3) | (52.1/47.9) | |||
2(2.2) | 1(1.0) | |||||
E2E2 | 0 | 0/2 | NS | 0 | 0/1 | NS |
(0/3.8) | (0/2.2) | |||||
48(64.9) | 54(58.7) | 45(59.2) | 61(63.6) | |||
E3E3 | 25/23 | 27/27 | NS | 21/24 | 33/28 | NS |
(62.5/67.6) | (67.5/51.9) | (61.8/57.1) | (66.9/60.9) | |||
1(1.0) | ||||||
E4E4 | 0 | 0 | NS | 0 | 0/1 | NS |
(0/2.2) | ||||||
13(17.6) | 20(21.7) | 18(23.7) | 16(16.7) | |||
E2E3 | 8/5 | 5/15 | NS | 9/9 | 6/10 | NS |
(20.0/14.7) | (12.5/28.8) | (26.4/21.4) | (12.0/21.7) | |||
3(4.0) | 3(3.9) | 1(1.0) | ||||
E2E4 | 0/3 | 0 | NS | 0/3 | 1/0 | NS |
(0/8.9) | (0/7.2) | (2.0/0) | ||||
10(13.5) | 16(17.4) | 10(13.2) | 16(16.7) | |||
E3E4 | 7/3 | 8/8 | NS | 4/6 | 10/6 | NS |
(17.5/8.8) | (20.0/15.5) | (11.8/14.3) | (20.0/13.0) | |||
16(10.8) | 24(13.0) | 21(13.8) | 19(9.9) | |||
E2 | 8/8 | 5/19 | NS | 9/12 | 7/12 | NS |
(10.0/11.8) | (6.3/18.3) | (13.2/14/3) | (7.0/13.0) | |||
119(80.4) | 144(78.3) | 118(77.6) | 154(80.2) | |||
E3 | 65/54 | 67/77 | NS | 55/63 | 82/72 | NS |
(81.3/79.4) | (83.7/74.0) | (80.9/75.0) | (82.0/78.3) | |||
13(8.8) | 16(8.7) | 13(8.6) | 19(9.9) | |||
E4 | 7/6 | 8/8 | NS | 4/9 | 11/8 | NS |
(8.7/8.8) | (10.0/7.7) | (5.9/10.7) | (11.0/8.7) | |||
Total | 148 (100) | 184(100) | 152(100) | 192(100) | ||
chromosomes | 80/68 | 40/104 | 68/84 | 100/92 | ||
(54.1/45.9) | (43.5/56.5) | (44.7/55.3) | (52.1/47.9) |