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Table 2 Genotype distributions and allele frequencies for G-308A mutation in theTNF-α gene in obese subjects and controls

From: The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution

  

Genotypes

Allele frequencies

 

n.

GG

GA

AA

G

A

Total obese subjects*

115

87 (75.6%)

26 (22.6%)

2 (1.8%)

0.869

0.131

   – Central obesity #

61

50 (81.9%)

11 (18,1%)

-

0.909

0.091

   – Peripheral obesity §

37

28 (75.6%)

9 (24.4)

-

0.878

0.122

Lean subjects

79

58 (73.4%)

19 (24.%)

2 (2.%)

0.854

0.146

  1. GG, GA, and AA = TNF-α genotypes. Total obese subjects includes 17 patients whom did not undergo biolectric impedance analysis * Total obese subjects vs controls: genotypes Χ2 = 0.21, df = 2, p < NS; allele frequencies Χ2 = 0.09, df = 1, p < NS. # Central obese subjects vs controls: genotypes Χ2 = 2.4, df = 2, p < NS; allele frequencies Χ2 = 1.4, df = 1, p < NS. § Peripheral obese subjects vs controls: genotypes Χ2 = 0.95, df = 2, p < NS; allele frequencies Χ2 = 0.16, df = 1, p < NS. Central obese subjects vs peripheral obese subjects: genotypes Χ2 = 0.5, df = 1, p = NS; allele frequencies Χ2 = 0.4, df = 1, p = NS. Cutpoints for centrally obese subjects were : WC 94 for men and WC 88 for women
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BMC Medical Genetics

ISSN: 1471-2350

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